This statistic reduces poison damage by a percentage as well as the chance to get poisoned. In Fallout 3 and Fallout: New Vegas, this statistic is hidden.
Fallout, Fallout 2, Fallout Tactics
- The Fast Metabolism trait sets initial Poison Resistance to 0.
- The Snakeater perk increases Poison Resistance by 25% per rank.
- The Vault City Inoculations perk increases Poison Resistance by 10%.
- The average NPC has a 25% Poison Resistance.
- In Fallout, Poison Resistance is capped at 100%, although it cannot be raised past 75%.
- In Fallout 2, it is capped at 95%.
Poison Resistance is also present in Fallout 3. It plays a much smaller part than in the previous games since only a few enemies (Radscorpions chief among them) use poison, and poison effects tend to be weak.
Example: A starting Endurance of 5.
- The Cyborg perk can increase resistance by +10%.
- The Survival Expert perk can add between an additional +2% to +6%.
Fallout: New Vegas
Fallout: New Vegas uses the same equation as Fallout 3, but Poison Resistance has much more use: there are Cazadores, Bark Scorpions, Nightstalkers, and weapon poisons, all in addition to radscorpions. In Lonesome Road, there are also venomous tunnelers. Moreover, poison in Fallout: New Vegas is generally much more lethal.
Honest Hearts perks
- Tribal Wisdom increases Poison Resistance by 25%.
Old World Blues perks
- Mile in Their Shoes - after consuming the Nightstalker Squeezin's, Poison Resistance is increased by 5%.
- Cardiac Arrest increases Poison Resistance by 50%.
- Heartless makes the player character immune to poisoning.
Items and consumables
- Gecko-backed leather armor, Gecko-backed metal armor and variants (+15).
- Wasteland tequila (+5, affected by Survival) and large wasteland tequila.
- Snakebite Tourniquet cures poison and +85 resistance (30s).
- Antivenom, Datura Antivenom and Fiery purgative cure poisoning.
- Hazmat suit (+85 resistance).
- Blood Shield (+50 up to +85 depending on the player character's Medicine).
Poison Resistance is not a derived statistic in Fallout 4. Acquiring it is only possible via four methods:
- Astoundingly Awesome Tales #5: Grants +5 Poison Resistance.
- Legendary Armor pieces with the Poisoner's modifier: Grants +25 Poison Resistance. A maximum of 5 pieces can be worn at once, totaling +125 Poison Resistance.
- Med-X: Temporarily provides +250 Poison Resistance.
- Tunnel Snakes outfit: Grants +10 Poison Resistance.
Poison damage inflicted to the player stacks and it is usually accompanied by a debuff to S.P.E.C.I.A.L. attributes. Almost all bugs inflict poison damage, some like radscorpions and the mirelurk queen can be quite dangerous.
- If the player boosts their Poison Resistance while already poisoned the S.P.E.C.I.A.L. debuff applied with the poison becomes permanent.
Poison Resistance is not a derived statistic in Fallout 76 as it can be directly influenced by the player; it is not derived from any other statistic and is not a function of any other value. Players can modify their own Poison Resistance in the same manner as other resistances, through armor, perk cards, or consumables. Poison damage comes from a small variety of enemies and weapons, such as the scorchbeast queen and bug grenade.
Poison Resistance can be acquired via the following:
- Poisoner's armor: +25 Poison Resistance (per piece).
- Funky Duds legendary perk: +50/100/150/200 Poison Resistance.
- Tato soup¹: +10 Poison Resistance.
- Cave fungus soup¹: +10 Poison Resistance.
- Grognak the Barbarian issue #3²: +15 Poison Resistance.
- Astoundingly Awesome Tales issue #9²: +15 Poison Resistance.
- ¹² These share the same buff and as a result, cannot be stacked with each other.