The company was interested in acquiring land in the Point Lookout area before the war in an attempt to modernize and encourage tourism. The company developed new homes and attractions, acquiring land from Constance Blackhall who agreed to sell after the death of her spouse. It was involved in the commercialization of natural gas, surveyed by the Bysshe Company. The People's Bank of Point Lookout was owned by Isla Negra.
The company is also referred to as Isla Negra Realty Company and Isla Negra Holdings.
- Fallout 3 loading screen: "Point Lookout remained very rural and isolated until the Isla Negra real estate company purchased land and began developing new homes and attractions."
- Fallout 3 Official Game Guide Game of the Year Edition p. 87: "The Blackhall family was deeply involved in the commercialization of Point Lookout in the early 21st century. Constance Blackhall, head of the estate after the New Plague made her an unexpected widow in 2058, cooperated with entrepreneurs from the Isla Negra Realty Company, who had been trying to acquire family real estate unsuccessfully for years. Despite overwhelming local cultural resistance, Isla Negra persistently attempted to bring tourism and modernization to Point Lookout and St. Mary's County."
- USS Ozymandias terminal entries; Bysshe Co. terminal, Mission parameters
- People's Bank of Point Lookout terminal entries; terminal, security updates