“A powerful and quick-acting steroid which gained popularity with athletes prior to the Great War. For a few minutes, it makes one stronger and tougher.”— Fallout: The Roleplaying Game Core Rulebook
- Buffjet -Introduced in Fallout 4, this variant is made in a chemistry station and is a combination of Buffout and Jet. Effect: Slows time for 15 seconds.
- Psychobuff - Another Buffout variant introduced in Fallout 4. Made in a chemistry station using Psycho and Buffout. Effect: +25% damage dealt, +3 Strength, and +3 Endurance.
- Bufftats - Another Buffout variant introduced in Fallout 4, this variant is made in a chemistry station using Buffout and Mentats. Effect: +3 Strength, +3 Endurance, +65 HP, and +3 Perception.
- Fallout 2 Official Strategies & Secrets p. 72: "Originally made popular through clandestine use by professional athletes, BufFout is particularly helpful in melee or unarmed combat."