The New Arrivals

The New Arrivals is a main quest $$

Background
With Appalachia repopulating, the Overseer wants to ensure the horrors that nearly caused humanity go extinct are put to rest. To deliver the death blow to the Scorched Plague and allow humanity to settle down permanently, she requests the assistance of the Vault Dwellers to help her convince the newly arrived Raiders and Settlers to inoculate themselves against the Plague.

Detailed walkthrough

 * The quest does not start until player characters are at least Level 20, triggering it, or after completing the quests for The Wayward with The Elusive Crane.

When the quest starts, one can tune into the overseer's radio station on the Pip-Boy 2000 Mark VI, where she will ask all Vault Dwellers to meet her at her new home in Sutton. The overseer's home can be found on the hill overlooking town to the east, across the railroad tracks leading south to Sutton Station. Upon entering, she will invite the player characters down to the basement, introducing them to her Mister Handy assistant Davenport, and inquire as to if they completed their original mission from her when they first left Vault 76 and followed her trail and that of the Responders to Charleston and the AVR Medical Center regarding the Scorched Plague.


 * Advancing this quest past this point requires the player to complete An Ounce of Prevention and to have been inoculated with the vaccine at AVR Medical Center.

Her reasons for asking about the inoculation are due to her concern about the new factions that have come to Appalachia. She asks the player characters to travel to Foundation at Spruce Knob to speak to the leader of the settlers and to talk to Rose about getting in with the raiders at their new main settlement, the Crater, at the crashed Valiant-1 space station, so as to give them the inoculation against the Scorched Plague. If they fall victim to the Scorched and scorchbeasts, it could be the events before Vault 76 opened all over again with the Scorched and scorchbeast queen able to get beyond Appalachia's borders to spread their influence due to a lack of cooperation between the various groups.

After the overseer asks the player characters to speak with the settlers and raiders, the quest will not advance until completing the first quests for both groups, which are Here to Stay for the Settlers and Strange Bedfellows for the Raiders, respectively.

Producing the inoculation
Once Paige and Meg have agreed to allow the settlers and raiders to be given the inoculation, report back to the overseer. She will explain the need to mass-produce the inoculation. With Intelligence or Perception 4+ the player character can figure out that she means using the Kanawha Nuka-Cola plant southwest of Charleston for the purpose since it's already fitted with the necessary infrastructure for experimental beverages.

The player character is asked to head over to the Nuka-Cola plant and clear it out. They must progress through the plant, facing enemies such as low-level feral ghouls outside and a glowing wendigo or legendary feral ghouls inside with the high-level feral ghouls. Then one may speak with the overseer. In combat, the overseer is marked as essential and cannot be permanently killed.

The first stop for the player character is the biometric scanner that can be found upstairs. The player character must use it to have their blood drawn for use in the Nuka-Cola, then use the device at the other end to mix the blood's antibodies into the formula. With Intelligence or Perception 8+, one can set up the sequence themselves (either directly splicing the antibodies in or cross-referencing with experiment logs), otherwise they can ask the overseer for help.

The player character must progress to the rear of the facility to reach the plant reactors, and bring them online. If one has Intelligence or Luck 8+, they can fix them immediately. Otherwise, they'll have to find spare power couplings.

The final stop is back in the snackability research and development department. The player character must access the manufacturing terminal by the entrance and select a name for the latest Nuka-Cola flavor. The choices are Nuka-Cola Vaccinated, Nuka-Cola Scorched, or Nuka-Cola My Blood's In It. They must also choose an age group (younger individuals, older individuals, or anybody who is sick and dying), garnering some witty banter from the overseer. Then one can head over to the manufacturing machine and hit the button to start the assembly line. After a few seconds, freshly-made Nuka-Cola Vaccinated will roll out of the machine, ready to be collected.

Delivery
The player character will now have the ability to craft Nuka-Cola Vaccinated as a healing item. Satisfied with now having the means to prevent the spread of the Scorched Plague among the newcomers to Appalachia, including the settlers and raiders, the overseer remains behind to continue making more of the inoculation while the player characters head out to deliver the first batch to Paige, Meg, and all their people, then report back to the overseer's house in Sutton for a progress report.

The player character can then visit Paige in Foundation and Meg at the Crater and give the inoculation to them. Both will be skeptical of it coming in the form of Nuka-Cola. Both can be convinced on the spot that it's the real deal, with a Charisma or Strength 4+ check for Paige, and a Charisma or Intelligence +4 check for Meg, which also earns a little extra reputation with the factions.

Once they accept the inoculation and thank the player characters for ensuring their people don't become the next victims of the scorchbeasts or their queen, the player characters return to the overseer's house to report mission accomplished. This completes the quest and begins the next one, Overseer, Overseen.

Davenport will also be available to talk to as a miscellaneous objective to start a daily quest as well focusing on the settlers and raiders, called Photo Opportunity.

Bugs
After retrieving the Nuka-Cola Vaccinated, disconnecting within the factory and going inside the building again after reconnecting, will make the steps to make the Nuka-Cola vaccine reappear, despite being able to deliver them already. The steps can be re-done, though the overseer will not be accompanying the player. Upon interacting with crafted Nuka-Cola, the option to pick them up will not appear, as the items are already in the player's inventory. The quest can be safely continued.