Desdemona

Desdemona is the leader of the Railroad faction.

Background
Desdemona's cautious nature and professional demeanor makes getting to know her difficult. It also leaves her history an enigma. If she is killed, Desdemona can be heard saying "Sam... I'm coming home..." in her final breath (to whom this may be referring to remains unclear.)

Other interactions

 * The Sole Survivor must seek her aid after dealing with the Courser, and getting his chip; as she and her people are the only ones who can decode it.
 * If the player does not speak to Desdemona prior to entering The Institute and accepting a mission, she shuns the player character and the Railroad questline ends.
 * If one is a Railroad agent but is Banished from the Institute then this also ends the Railroad questline as the player remaining undercover was vital to the plan. Desdemona encourages the player to stop the Institute with the Commonwealth Minutemen as she sees it as the best remaining option for protecting the synths.

Bugs

 * It is possible that during and after Glory assists the player during the quest Memory Interrupted she can either become stuck in the area or die, resulting in a halt to progress during the quest Underground Undercover when the player must warn Desdemona of the impending Brotherhood of Steel attack. This is because Glory is involved in a dialogue with the player during that event. To avoid this, the player should follow Glory out of the Malden Center Station as she can become stuck on metro gates or other objects.
 * After completing the main quest line with the support of the Commonwealth Minutemen, if you are on good terms with The Railroad and you return to their hideout, Desdemona will speak of Glory as if she had died even though you'll see Glory walking about. If you try to interact with Glory she will stay silent and not say any dialogue.

Appearances
Desdemona appears only in Fallout 4.