Uncle Leo

Uncle Leo is a friendly, wandering super mutant. He is an exile of sorts from the super mutants; he ran away before he could be killed, because he was sowing peace/dissent among his kin. Since then, he has roamed the Capital Wasteland and can be encountered in a random encounter. He frequently refers to the Vault 101 Dweller as either "Little Brother" or "Little Sister", depending on the PC's gender.

Interaction
When speaking to Uncle Leo, he will be surprised that you haven't shot at him yet. As long as you're nice to him, you can get more than information. When the option comes in at the top to tell him to give you his goods (essentially robbing him), he gladly imparts a suit of Dirty Pre-War Businesswear to you as a gift, wishing he could give more.

Asking him what he meant when he said "before I became this" causes him to tell the player that Super Mutants are not born, but are made by other Super Mutants in a cold, dark place. He mentions that they use the captives that they take to make more of themselves, but doesn't know, or explain, how. Depending on when he shows up and how the player chooses to explore, this could be the game's first reference not only to what Super Mutants do with their captives, but how they come into being.

Given the canonical method of Super Mutant creation, this may be an indication that The Master's experiments are being continued, perhaps without true understanding of why, by the surviving Super Mutants. This would also imply that there is another FEV vat located somewhere in the DC Wasteland to which they take captives in order to be dipped and transformed (the player may also overhear Super Mutants chatting about making more of themselves with "green stuff" in Vault 87, which would seem to confirm this).

Not much is known about encountering Uncle Leo, except that he has been seen near the car dealership south of Megaton, whereupon he makes his way to the ruined house nearby and stops there. He has also been encountered in Reclining Groves Resort Homes and also near the Scrapyard. Uncle Leo is believed to be a random encounter event type, see the random encounters article for other possible locations where he can be found.

Uncle Leo can be encountered at least two times around the Capital Wasteland; at the second time you meet him he will tell you how after your first encounter with him he fell into a dark cave while climbing a hill and hurt his leg. The cave turned out to be an old basement in which there was stacks of purified water. He tells you that after he got out of the basement he has been hunted by a group of "bleeders" (as super mutants refer to humans) and that he was forced to abandon the water he was carrying. Like during the first encounter, he will offer you another suit of Dirty Pre-War Businesswear, wishing he could give you more.

Attacking Uncle Leo causes him to switch to hostile. However, once the game finishes running the attack animation, Uncle Leo returns to friendly, even when the player is obviously his tormentor. Attacking and/or killing him causes no change in karma.

You can kite (engage in combat, and then run in a specific direction) any nearby mobs towards Uncle Leo, who will attack them for you. This is especially helpful for swarms of Mirelurks or Super Mutant Masters.

Appearances
Uncle Leo appears only in Fallout 3.

Behind the scenes
Uncle Leo is possibly a reference to Elder Scrolls IV: Oblivion, because there is a friendly zombie with the same name living upstairs of a Muurine's house in Crucible, New Sheoth in the expansion Shivering Isles.

Quotes
"'...Super Mutants, I mean. We aren't born this way. We are created.'"
 * - Uncle Leo