A Meeting of the Minds

 is a Fallout 3 quest and achievement that is added to the game with the Point Lookout add-on.

Walkthrough
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Who to kill?
You and Desmond will eventually reach Calvert's room, where you'll see the Brain himself in a massive glass tank surrounded by inactive Protectrons. Desmond and Calvert will have a short conversation, each of them claiming to have your support. Eventually you'll be forced to decide which of them to kill. If you speak to Calvert, he'll offer the greatest thing any human could ever hope for in exchange for your killing Desmond. You now have a decision to make...

Killing Calvert
If you decide to side with Desmond, simply shoot at the Brain's glass tank until the glass shatters, preferably with a missile launcher or a Fat-Man (although an automatic weapon will do fine). After the Brain is dead, any remaining robots will be disabled and you can talk to Desmond. He will be overjoyed to have finally won and remarks that everything that Calvert stole from him is finally all his (although he's still a bit rude to you). He will also give you a key which unlocks the nearby door. Inside this door are 2 ammo-boxes, a safe, 2 first aid boxes, some energy weapon ammo, some misc. items, and of course, the Microwave Emitter. The room also has a ladder leading outside.

After speaking to Desmond again, he will tell you that after he's done in the lab he will go north to confront another one of the "players". He refers to this contest as a "microcosm of the old world".

Killing Desmond
If you decide to kill Desmond, the Professor will reward you with the greatest thing any human could ever hope for... DEATH! At least he'll try, at which point he'll send some of the previously inactive protectrons after you.


 * Desmond doesn't need to be alive in the end, you can kill them in either order, and come out with the same loot. After killing the professor without Desmond, the door mentioned will automatically unlock, giving you access to the Microwave Emitter, and a way out.

Note
After you exit via the ladder you may be attacked by a smuggler with a sniper rifle on an island to the south. The smuggler is beyond detection range and will not show up on your radar. His fire is extremely accurate and he will continue to fire at you even if you crouch and your status is [HIDDEN].

Bugs

 * Sometimes when you reach the first door that slams shut and requires you to hack or find a card, if you decide to hack it, when the door opens the player will not be able to proceed, an invisible barrier is blocking the door. This is occasionally happens with others doors. To fix this, simply save where you're at then reload the save. You should be able to go through the door.
 * Some ammo boxes, items and containers cannot be opened; they can be reached by using the console command through the floor.