Break Manson and Franc out of prison

Speak to Jacob the Chemist, and tell him you don't like the super mutants. He will tell you to break their friends out of jail. Go to the jail and wait. Eventually the super mutant standing guard will wander towards the door. At this time, you can pick the lock of the cells and free the two convicts. You can also Steal the key from the guard, and use it on the door when he leaves. Either way, you have to wait until the guard leaves to free them, as when nearby the guard stops you.

Thanks to you, the anti-mutant conspiracy goes on, and your karma takes a hit. This also opens up the quest to blow up the mine's air purifier.

Once you receive this quest, you can instead turn Jacob in to Marcus for 2500 xp. Alternatively, you can perform the break, then turn them in to Marcus.