Don't Make a Beggar of Me

 is a quest in Fallout: New Vegas.

Quick walkthrough
Travel to the Great Khan Encampment and speak to Melissa to begin the quest. You must be in good standing with the Great Khans or she will refuse to allow you to help her.
 * Do not finish Don't Make a Beggar of Me before the quest Oh My Papa because after Don't Make a Beggar quest is complete Melissa leaves the game, and short of console management is gone for good.

Travel to Sloan and search Chomps Lewis' office for the suitcase.

Speak to Chomps and then travel to Primm to speak with Tyrone.

Obtain the chems from Tyrone.

Return to Melissa to complete the quest or inform Lieutenant Hayes about Tyrone's smuggling to complete the quest.

Detailed walkthrough

 * Travel to the Great Khan Encampment and inquire about why Melissa is there to begin the quest.


 * Travel to Sloan and enter the Mining Office. Walk up the stairs and examine the empty suitcase to the left of the desk.


 * Go outside and speak with Chomps Lewis and inquire about the empty suitcase to find out about Tyrone.


 * Travel to Primm and find Tyrone at the NCR camp in the tent next to Lieutenant Hayes' tent.


 * When you question him about the chems, he explains that his superiors are getting suspicious and that the business is riskier.  He will ask for an additional 300 caps which can be paid to obtain the chems.  With a Strength of 7, Speech of 40, Black Widow Perk or Barter of 35, you can bully Tyrone into giving the chems outright with no penalties.  You can also shoot Tyrone and take the chems, but that will result in NCR fame loss and negative karma.


 * Once the chems have been obtained return to the Great Khan Encampment and give the chems to Melissa.


 * (Optional) You can inform Lieutenant Hayes in his tent about Tyrone's smuggling. If done, Hayes will take the chems and inquire if anyone else was involved.  Chomps Lewis can be ratted out or Hayes can be told nobody else was involved.

Rewards

 * Giving the chems to Melissa earns fame with the Great Khans, 150 caps, and some chems.


 * Helping Lieutenant Hayes earns fame with the NCR, and increased Karma.


 * Returning to Melissa, after informing Hayes about the smuggling, and telling her you turned in Tyrone results in her and the two Khans attacking. Melissa has a large number of caps in her possession.


 * Returning to Melissa, after informing Hayes about the smuggling, and telling her Tyrone was sloppy, or lie about what happened, results in 85 caps and 100XP.

Bugs

 * Apparently there is no way of completing the Oh my Papa quest if you speak to Melissa first and do her "Don't Make a Beggar of Me" quest. It does NOT matter if you turn her in, or if you give her the chems.  When you get the "Oh my papa" quest the marker is at the Great Kahn Encampment but she is not there.  The very act of completing the quest makes her dissapear.
 * If you are playing on the PC you can use console commands to fix this glitch.