Capital Wasteland super mutant conflict

The Capital Wasteland Super Mutant War is a war between the citizenship of the Capital Wasteland as well as the organizations in the region, and the Vault 87 super mutants. The wastelanders have fought the super mutants from 2078 to the present day. The Capital Wasteland Brotherhood of Steel have fought the super mutants since 2255 onwards. By 2277, the other factions fighting the super mutants are Talon Company, who lead a full on war with them, Reilly's Rangers, a mercenary group who are contracted with sweeping them from the ruins, the Brotherhood Outcasts from 2276, and finally the native raider gangs, settlements, and citizens.

Prelude
Vault 87's project was to partake in the Evolutionary Experimentation Program, subjecting inhabitants to the Forced Evolutionary Virus. These particular experiments resulted in their mental faculties diminishing. They were generally less intelligent and more aggressive than their West Coast counterparts. More unlike their distant cousins, they retained less of their humanity after transformation, and no distinguishing features from their former lives could be found.

Despite their apparent lack of intelligence, the mutants were somehow able to organize themselves into a coordinated army (as evident from numerous raids). They had also procured large amounts of advanced weapons, ammunition and equipment, and maintained the FEV infrastructure necessary to transform humans to increase their numbers. In 2078, the super mutants set out to capture human captives in order to expand their army, as well as find a new source of FEV.

War
The super mutants terrorized the denizens of the Capital Wasteland for the next two centuries, and were widespread and rampant throughout the entirety of the wilderness. When the Brotherhood arrived in 2255, they fought a long crusade against them, and managed to almost entirely restrict them to the ruins of Washington, D.C.. The Brotherhood have endlessly fought them since then, setting the front line around the borders of D.C. In 2277/2278, the Lone Wanderer raided their headquarters at Vault 87, and dealt decisive blows to their military strength and organization, with the Enclave also discovering and raiding the base afterwards. The Lone Wanderer could have informed Elder Owyn Lyons of Vault 87, with him setting out plans to eradicate the super mutants once and for all by attacking the Vault.

Aftermath
After the conclusion of Broken Steel, the super mutants are extremely fractured, and have almost been driven extinct. They are running out of FEV, and have lost their headquarters and breeding ground of Vault 87. The Brotherhood of Steel has began further closing in on D.C., backing them into a corner.

Appearances
The Capital Wasteland Super Mutant War appears in Fallout 3 and its add-on Broken Steel.