The AntAgonizer

AntAgonizer is a quest character in Fallout 3 located in the Canterbury Commons. She possesses control over giant ants and is fighting her nemesis, the Mechanist. She is dressed in an ant costume, emulating a comical supervillainess style persona.

Character
Talking to Joe Porter reveals that her name is Tanya Christoff and also reveals her background.

Her family was killed by ants when she was young, and she has since taken on the belief that ants are superior to humans, citing their instinctual willingness to work together to accomplish goals unlike humans' desire to kill one another through warfare.

A terminal in Hubris Comics contains a letter to the editor that mentions the AntAgonizer as one of Grognak the Barbarian's villains. The letter expresses sadness as the villain was "never developed fully". The AntAgonizer's background story matches the comic book and she was to appear in Grognak and the Ants of Agony, but the comic was thrown out due to bad writing. The author of that letter mentions Mr. Moorellis, a reference to the well-known comic book writers Alan Moore and Warren Ellis.

Quest
The Lone Wanderer can receive a quest to stop the AntAgonizer's battle with the Mechanist. The quest has two paths by which to proceed:
 * 1) The Lone Wanderer can convince the AntAgonizer to halt the attack by one of three ways. You will need to perform the side quests of asking the townspeople about the AntAgonizer before you are offered the dialogue to pacify her.
 * 2) Reading the letter in the Hubris Comics terminal before encountering the AntAgonizer
 * 3) By performing a Speech check (which, incidentally, is the hardest you'll encounter in the game. To calculate you exact chance of success, multiply your Charisma with your Speech skill, and then divide by 420).
 * 4) By having the Lady Killer perk
 * The player can then take the AntAgonizer's Costume to the Mechanist and exchange it for the Protectron's Gaze unique gun.
 * 2. The Lone Wanderer can instead convince or kill the Mechanist to obtain his costume. After you speak with Derek in Canterbury Commons and have the perk Child at Heart, you can use Child at Heart on the Mechanist and he will give up his costume. The Mechanist's Costume can then be exchanged with the AntAgonizer for the Ant's Sting unique knife. This results in Bad Karma.

If the player attempts to talk to the AntAgonizer while wearing the Mechanist's costume, she will attack even after agreeing to give up her life as the AntAgonizer.

Trivia

 * AntAgonizer is possibly a reference to Antagone of the Adult Swim program Frisky Dingo. Antagone gains super strength and the ability to command ants after being exposed to radioactive goo.
 * AntAgonizer's costume resembles the Japanese Superhero Masked Rider.