Mr. House

Mr.  is the king of New Vegas living in the Mojave Wasteland in 2281. House is responsible for the creation of Mr. New Vegas.

Background
Mr. House was born and lived before the Great War. Before the Great War commenced, he was President, founder, and CEO of RobCo Industries. He supposedly froze himself and waited in stasis for a long amount of time (which is the reason he's over 200 years old) until he was woken up and emerged into a city that was falling apart. He is an elusive man, and also plays a big part in why New Vegas was not directly hit by the nuclear devastation.

He lives in the Lucky 38 and is in charge of the securitrons that roam Vegas. At some point after emerging he won Vault 21 in a bet and has since converted it into a casino/hotel.

Mr. House is extremely decrepit and can only live inside a self contained unit, the player later has the opportunity to break through his security and see his true decaying form. However, opening his isolation chamber, even for a second, means that Mr. House will die within a year from exposure to outside contaminants.

Interactions with the player character
Mr. House hires the Courier to eliminate local New California Republic activity in order to maximize his influence over the strip.

SPOILERS

It is possible from the charaters first interaction with Mr. house to kill him. The terminal on the wall on the left (facing Mr. House) will open a secret Annex. A second terminal beside the lift door will grant you access to his hidden chamber. The player can easily evade the robots and run for the lift.

Upon reaching his chamber, the player can do 3 things - leave him be, Open the chamber and expose him to germs giving him a year or so to live, rip out a part of the machine, leaving him alive but unable to control anything, or sterilize the chamber killing him ( or just shoot the bastard )

It is worth noting that there is no required science skill to hack the computers, no required medical / science skill to open his chamber and alter this machine which seems strange. it should be that Mr. House would have been more secure about his greatest weakness, AND being a computational genius he would have had more than the ability to do it.

Behind the scenes

 * In casino parlance, the house refers generally to the gambler's opponent, the casino itself, as in the idiom, "The house always wins."
 * "He's very much inspired by Howard Hughes," says J.E. Sawyer in the Game Informer Fallout: New Vegas preview article May 2010.
 * It is worthy of note, that his initial appearance is reminiscent of the Wizard of OZ.

Appearances
appears in Fallout: New Vegas.