The Brain (Point Lookout)

Professor Calvert (also known as The Brain and The Transcendent One among the tribals) was one of the inhabitants of Point Lookout in the years 2077 to 2277 and serves as the main antagonist of the Point Lookout add-on.

Background
Professor Calvert, once a brilliant government scientist, is now reduced to a power-mad brain in a jar. He retains his brilliance, but hundreds of years in isolation have left him a maddened, scheming figure, constructing elaborate plans to dominate the rest of the world. Now that he has a way of contacting people outside of his lab, he intends to follow through on his plans, especially if he can include revenge on Desmond, the agent responsible for his lack of a living body.

Pre-War
Professor Calvert was a member of the prestigious and influential Calvert family before the Great War, and an accredited expert in the field of cognitive robotics. He survived the war by extracting his brain from his body and preserving it in the underground lab using experimental robobrain technologies. This technology has allowed him to survive for over 200 years and develop the ability to telepathically communicate with other people over long range.

Brain in a jar
His ultimate goal is to use his powers to achieve "psychic domination" over the Maryland area. Standing in the way of this goal is Desmond Lockheart, who was the one responsible for Calvert's lack of a body. The battle of the two rivals continues as the professor becomes a "god" to a local tribal cult. Despite the cult's usefulness as living agents and tools, the Professor is frequently frustrated by their misinterpretation of his orders as religious instruction. After the tribals fail to kill Desmond and destroy the psychic jamming device, he learns (by contacting the mind of the Lone Wanderer) that the jamming device is ready to be installed on the top of the Ferris wheel to completely block his powers. Calvert then asks the Lone Wanderer to destroy the device rather than install it.

Quests

 * Hearing Voices: The Lone Wanderer speaks to Calvert in Jacksons' inner sanctum, he instructs them to find a way to destroy Desmond's jamming device.
 * Thought Control: Desmond gives the Cogwave jammer to the Lone Wanderer and instructs him/her to place it on the Wonder Wheel. Before they can, Calvert telepathically orders the Lone Wanderer to throw the jammer in the trash compactor.
 * A Meeting of the Minds: The choice arises whether to kill Calvert or Desmond. However, the Lone Wanderer must kill Calvert in the end regardless of their choice.

Effects of player's actions

 * The Lone Wanderer must choose to kill either Desmond or Calvert at the end of the Meeting of the Minds quest; However, Calvert must be killed regardless of outcome.

Abilities
Professor Calvert is physically a human brain in a jar. He has the ability to control robots within the underground lab, and can access the minds of other people from a great distance. Though his psychic powers are strong, they are limited to the area immediately around him because of Desmond Lockheart's jamming device. He also controls a local tribal cult through a holographic projector he entrusted to Jackson, the cult leader. Due to his ability to speak telepathically to various people, Jackson's cult believe Calvert to be a type of deity.

Appearances
Calvert (brain) appears only in the Fallout 3 add-on Point Lookout.

Behind the scenes
A living brain in a jar/vat is a common device in sci-fi movies, TV shows, games, and literature.