Skunk

A giant catfish is a sea creature mutated from the common pre-War Catfish. According to a California fisherman, in 2161, a three-eyed giant catfish he called Skunk keeps scaring other fish away from his spot.

Appearances
The giant catfish is only mentioned in-game by a fisherman in Fallout.

A humanoid, mutated catfish known as a "catfish Mirelurk" also appears in The Art of Fallout 3, the art book available with the collector's edition of Fallout 3. However, only the regular Mirelurks (mutated from crabs) and the Mirelurk Kings (mutated from turtles) appear in the actual game.