Wild Card: Change in Management

 is a quest in Fallout: New Vegas.

Quick walkthrough
Once you discover Yes Man, he will explain Benny's plan for killing Mr. House and taking over Vegas. The player will then be able to choose to continue Benny's plans and taking on this quest. You will have to head towards the Lucky 38 penthouse, locate the chamber in which Mr. House actually resides, and choose to either disable or kill him. After killing Mr. House, meet Yes Man outside The Tops casino and accompany him to Lucky 38.

Detailed walkthrough
After entering the Lucky 38 penthouse, look for a terminal on the wall near Mr. House ( you need science level 70). This terminal will allow you to unlock a hidden door leading to Mr. House's chamber. Note that, after activating the door, an alarm will sound, and the securitrons will become hostile. Behind the hidden door, there is another terminal, as well as several securitrons which will attack on sight. Activate the terminal in this room as well, to head on to the control room.

Once in the control room, there is one final terminal. Activate this terminal to release Mr. House's isolation chamber and expose him to the outside world. You can then talk to him, and decide his fate. Note that once the isolation chamber has been opened, regardless of the fate you decide for Mr. House, he will die within a year from exposure to outside contaminants.

To pass the initial terminal you can choose to either pass a Hard difficulty hack or execute an Executive Override and obtain the password to the terminal from either H&H Tool Company or the hotel in Camp Golf.

If you decide to kill Mr. House, you will receive the note A Tragedy Has Befallen All Mankind, and the quest The House Has Gone Bust! will instantly be started and failed.

The quest is complete once you either kill or disable Mr. House.

Bugs
XBox 360 and PS3: After disabling House the objective does not check off which prevents Yes Man from meeting you outside Lucky 38. (Double check that you have selected the option to permanently disable House from all systems on the same console used to wake him from the chamber)

PS3, Xbox 360 and PC: Securitrons may not become hostile