Vault 81

Vault 81 is one of the vault series of fallout shelters developed by Vault-Tec. This vault is located in the Commonwealth.

Background
Vault 81 is unlike almost any other known vault in the Commonwealth, in that it still contains sane and active dwellers. After a simple quest requiring either three fusion cores or a successful speech check, the Sole Survivor can gain entrance and meet the vault dwellers.

Vault-Tec created Vault 81 with the purpose of developing a single, universal cure for every sickness that humanity could possibly suffer from, using the residents as human test subjects. The vault was divided into two separate areas; the main vault, where up to 96 residents would make their home for the foreseeable future, and the secret vault, where Vault-Tec scientists would conduct their research and observe the residents as they were unknowingly exposed to different diseases and cures. The diseases were released via propellant nozzles hidden within the resident's rooms. In the case of an evacuation of the vault, all main vault residents were to be incinerated with the same propulsion nozzles.

The first vault overseer, Dr. Olivette, was skeptical of Vault-Tec's goal and possible use of human experimentation and planned to blow the whistle if it was unethical, however, when she received her full briefing she found out the true unethical nature of the experiment and that Vault-Tec had major backers in the federal government and blowing the whistle will do nothing. Dr. Olivette was determined to not let the residents of the vault be used as guinea pigs and tried to think of a plan. On the morning of the Great War, Dr. Olivette received the "call" to start the notification of staff and residents, but sabotaged the call list so the science staff wouldn't be notified and report in. Her plan mostly worked; however, three of the science staff turned up with two living nearby, Kenneth Collins and Jim Flint, coming over with the general population, and the third one, Burrow, visiting to ask when the next drill would be. As the three scientists worked to create their cure, Olivette watched over all of their data and personally had to approve the scientists moving onto Phase II, animal testing, and Phase III, human testing on unknowing participants.

Before human testings could begin, Olivette disabled the delivery systems, cutting off the scientists from infecting the vault dwellers. Additionally, she also sealed all access points to the secret vault, leaving the three scientists to die. To prevent any commotion within the general population, Olivette kept the vault's true purpose, and the existence of the secret vault, a closely guarded secret.

Isolated from the other side of the vault, the scientists continued to use animal testing with their last remaining population of mole rats. To help with the research, Dr. Collins modified a Miss Nanny lab assistant to take on greater responsibilities due to the staff shortage, creating Curie. When the scientists eventually died of old age, Curie remained and worked on the cure alone, spending decades conducting trial after trial. She achieved the vault's objective in 2204, perfecting the universal cure. Although Curie had reached a level of self-awareness over the years, however, she was unable to overcome her original programming, which required authorization from a Vault-Tec employee before she could leave the vault and begin a new line of research. She patiently idled in the secret vault for decades, awaiting a response from vault security.

Meanwhile, the residents in the main vault went on with their lives, completely unaware that anything was amiss or that they had been intended as test subjects. In 2277, Overseer Baht opened the vault for the first time, allowing communication and trade with the outside world. Although this provided a badly needed source of food and other vital supplies, especially parts and tools to repair the vault's deteriorating systems, many residents maintained an isolationist or even xenophobic mindset, distrusting any outsider who was allowed to enter.

By 2287, one of Vault 81's dwellers, Bobby De Luca, had discovered one of the entrances into the secret vault and used it to store his drugs. Austin Engill witnessed Bobby opening the door and went in to investigate. He was bitten by one of the lab mole rats, which had escaped containment and started a colony in the secret vault decades before. This nest was still infected with the various diseases used in the experiment, resulting in Austin gaining an unknown lethal disease. When Bobby revealed the existence of the secret vault, the Sole Survivor agreed to search it for a potential cure. Inside, the Sole Survivor discovered Curie who handed over the last unexpired dose of her universal cure. The Sole Survivor could either use it on themself, leaving Austin to perish and earning the animosity of the vault dwellers, or turn it over to save Austin and be granted a room in the vault by Overseer McNamara and appreciation throughout the vault.

Notable loot

 * Syringer rifle - Reward from the quest Hole in the Wall.
 * Medicine bobblehead - In Curie's laboratory, during the quest Hole in the Wall.
 * Mini nuke - In the broodmother's room, inside a tipped over locker, during the quest Hole in the Wall.
 * Stealth Boy - In same room as the Vault 81 tech password, during the quest Hole in the Wall.
 * Fusion core - Reward from the quest Here Kitty, Kitty, and one during the Hole in the Wall.
 * Overseer's Guardian - For sale at Alexis Combes' shop. She also has Destroyer's right leg and overseer's armor.
 * Taboo Tattoos issue #16 - In Horatio's barbershop.
 * Grognak the Barbarian issue #5 - In the classroom, as a reward for the side quest Short Stories.
 * Overseer's room key - on Jacob Forsythe and Gwen McNamara, opens sliding door in the overseer's room.
 * Vault 81 security key - on Scott Edwards and the vault security personnel. Gives access to various doors in Vault 81.
 * Vault 81 tech password - in the Secret Vault 81 research comm room, during Hole in the Wall. Gives access to nearby secure access terminal.
 * Teddy bear - A unique clean variant can be found in a box before one of the beds in the northeast bedroom.

Related quests

 * Vault 81
 * Hole in the Wall
 * Here Kitty, Kitty
 * Short Stories
 * Dependency

Appearances
Vault 81 appears only in Fallout 4.

Gallery
Vault 81 Refugio 81 Refúgio 81 Убежище 81