Purified water

Purified Water is (as the name suggests) water that is completely free of radiation and so it can be safely consumed without harming the player. In addition, it also heals far more then Dirty Water does by awarding 20 Health instead of 10. It's relatively rare in the Wastes, but can be requested by Wadsworth, the robot that takes care of the players house in Megaton or Godfrey in Tenpenny Towers (depending on player's choice of quests).

Purified Water can be given to Micky outside Megaton, Carlos outside of Rivet City, or Willy in front of Tenpenny Tower. You can exchange a bottle for positive Karma; this introduces the possibility of infinite Good Karma, as none will ever stop asking for more water.

There also seem to be random occurrences in the wastes of water beggars. If you deny certain ones water they request to be shot in the head (for negative karma, of course...just not for denying them sustenance). In another random occurrence, you may encounter two groups fighting over a fridge stocked with 10 Purified Water bottles. You can leave them alone, kill them and take the water, or with a successful Speech check, convince them to split the water with you.

There is a mini-quest outside of Arlington Library (possibly triggered after The Waters of Life?) which involves a Wastelander requesting you kill a Radscorpion guarding a refrigerator full of purified water outside Alexandria Arms. She then allows you to take all or some of the water.