Fallout 4 Bugs

Crashing, freezing and other hardware- or software-related issues

 * Game random crashing/freeze often enough to make game play frustrating. Using Beta version seems to have resolved this. See instructions here http://gearnuke.com/fallout-4-download-1-1-30-beta-update-fix-pc-crashes-related-xaudio-drivers/#
 * When talking under water the game crashes.
 * When using multiple monitors with Nvidia SLI, the lower half of the view will have a dark band.
 * Custom resolutions for multiple monitor setups require editing Falloutpref.ini file.
 * Disabling "Windowed" mode in settings with NVidia SLI enabled and using multiple monitors will cause crash on loading screen.

Menu-, HUD-, inventory-, and radio-related bugs

 * Settlement UI for food resources can glitch out displaying duplicate food icons for plantable food and some plantable food icons may disappear but is still selectable.
 * Occasionally the pip-boy texture will fail to load, rendering the in-game menu invisible, but tooltips and keyboard controls continue to work. This can be fixed by reloading from a quicksave.
 * In first-person view the players weapon may disappear from the screen, even though the weapon isn't holstered. Holstering/unholstering doesn't fix this but switching to third-person and back does.

Physics engine glitches
When talking to a companion in a moving elevator it is possible for player character to fall through the floor and die.

Graphics glitches
(current working fix http://www.nexusmods.com/fallout4/mods/143/?)
 * When using the "TCL" Console command in Diamond City, all characters nearby seem to have disappearing eyes.
 * When using unsupported resolutions, such as a 5:4 monitor with 1280x1024 resolution, the lockpicking interface will be invisible.

Non-player character-specific bugs

 * On PC latest patch, equipping Settlement NPC's with armor then equipping them with the exact same armor that they are already wearing will cause an instant crash to desktop.
 * Companions may encounter issues where they will follow, but not run or fast travel. If they are too far from the player when entering a door, they will not follow through the door. The player can initiate speech but will not be able to enter companions inventory.

Quest-specific bugs
Please place quest specific bugs on their respective pages. (Fallout 4 quests)

Location-specific bugs
Please place location specific bugs on their respective page (Fallout 4 locations)

Gameplay bugs

 * High FPS (110<) can cause character to become un-movable requiring a save reload after exiting a terminal.
 * Might be caused by exiting a terminal quickly.
 * When subtitles are on, conversations can become 'stuck' on screen with part of the conversation subtitle remaining while the conversation continues. Text is removed from screen when conversation is complete.
 * Sometimes text options do not show up in dialogue and NPC comments that the player character has not responded. A response can be selected by pressing the correct button but the text doesn't appear.
 * When saved near mine, stepped on that mine (causing explosion) and load saved game mine is gone.
 * If player character changes their name inside Vault 111 before taking the lift to the surface, the player character can not walk off platform or enter Pip-boy. Looking, jumping, and shooting functions still work.
 * Unable to draw weapon, use greandes, or pull up VATS after fast traveling.Fixed by zooming out into 3rd person view then back into 1st person view.

Xbox One only bugs

 * The player character doesn't speak, his/her dialogue is skipped entirely.

PC only bugs

 * Tab key stops working seemingly randomly and unable to access PipBoy or go back in the menus with it.
 * Pressing the ESC key to get back to main menu, then return back into the game can fix this, without restarting game.
 * Going into the trade menu and clicking the "TAB)EXIT" button on the bottom can fix this.
 * Inability to access PipBoy may be caused by Steam Overlay on PC version. If one accesses the Steam Overlay using a combination that includes the tab key, but exits the overlay with a different key combination (such as hitting the Esc key), the tab key will become unresponsive in-game. This can be fixed by opening, and then closing, the Steam Overlay with the selected key bindings. For a more permanent solution, please consider rebinding Steam Overlay to a combination that does not involve Tab key.
 * For some users when using VATS, Workshop, or upgrading your power armor, the outline glow of a highlighted object will be replaced with a static glitch that takes up the whole screen and displays the same color as the normal outline would show. No patch yet but it does not effect anything else but your vision.