Hole in the Wall

Hole in the Wall is a side quest in Fallout 4.

Detailed walkthrough
After donating blood to Dr. Forsythe, leave the vault and either pursue the Here Kitty, Kitty quest to find Ashes or else wait for 24 hours or more before returning. You may have to complete another quest in addition to waiting 24 hours before the next scene will trigger. Austin will have been moved to the vault hospital. Speaking with Dr. Penske begins the quest Hole in the Wall.

Austin, a boy from Vault 81, was bitten by a mole rat when wandering in the secret portion of Vault 81 and subsequently falls ill. The player character must follow Bobby De Luca to the secret entrance located in the reactor room. They are asked to go into that part of the vault and find a cure. During the investigation, the true purpose of Vault 81 is discovered. The password to the locked terminal is next to the research comm terminal in the subsequent room. After this the player finds a robot named Curie who has manufactured the cure; however, there is only one dose left. The player character must decide - give it to the boy (who is in a coma now) or use it on themselves, if during the quest the player character also was infected with the mole rat disease.

Options

 * Give Austin the cure: If the player character gives the cure to the boy, they receive rewards including the syringer rifle and a room in Vault 81. Most chems and other objects throughout the vault are no longer marked as owned and can be freely picked up without angering the residents. As a side effect, if the player character has contracted the disease during this quest, they keep the disease permanently (-10 max HP).
 * Use the cure on themselves: If one uses the Vault 81 cure on him/herself, Austin dies and everyone in Vault 81 blames the Sole Survivor. A small memorial for him is prepared in the classroom under the "America lives on ... in you" poster, consisting of a candle, a new teal flared vase, a toy car, a baseball glove and a teddy bear.

Either way, the quest concludes and Curie asks to accompany the Sole Survivor around the Commonwealth in order to further her scientific research, becoming available as a companion.

Bugs

 * The cure can be used on both the player character and Austin if, during the conversation with the doctor, the player tells him to use the cure on Austin then quickly backs away and uses the cure on themself before it is removed from the player's inventory. Note that you have to use the cure after Dr. Forsythe begins responding, otherwise you will trigger the dialog for having used it yourself. Using jet before talking to him helps you with this considerably.
 * If you leave the vault before Bobby opens the secret door, he will have gone into the secret vault with the secret door still being closed, making it impossible to finish the quest.
 * If leaving the hidden vault with the security key holotape in the inventory one will no longer be able to access the locked door to get the cure as the terminal which opens it will not register that the Sole Survivor has the holotape anymore. Sometimes this will happen even if one does not leave the vault, and progress will become impossible without cheating.
 * Dr. Penske will not be in the room discussing her grandson's illness with Dr. Forsythe and will not start the quest. One can go to Dr. Penske's office and talk to her there to start the quest.
 * If companions or other NPCs are bit by mole rats, they will "contract" the disease and add it to the player's list of active status effects as though the player was bitten.

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