Desmond Lockheart

 is a ghoul inhabitant of Point Lookout.

Desmond is a British ghoul who, before the Great War, used to be a secret agent. He now lives in the Calvert Mansion, which is constantly being attacked by a tribal cult that believes the mansion is destined to burn down. Despite what may seem like a crazy religious following, they are actually being manipulated by the brain of Professor Calvert, whose only goal has been to crush Desmond for over 200 years. Part of Calvert's goal is to destroy a jamming device in Desmond's possession. This would allow Calvert to further spread his inhuman powers of direct manipulation across all of Point Lookout. The tribals attempt to overwhelm Desmond's fortified mansion, attempting to kill the foul-mouthed Ghoul, destroy the device, and burn the mansion to the ground, but fail due to the Player Character's interference. This is how the eerie main story arc of Point Lookout begins.

Some of the dialogue from Professor Calvert hints that Desmond is British. His accent, and dialogue phrasing, seem to confirm this. It is unclear whether Desmond was based in the US when the bombs fell, or if he crossed the Atlantic after the war, as Allistair Tenpenny did.

Quotes

 * "So, my hero huh? Think you came in and rescued me right in the nick of time?" -- When you speak with him for the first time.
 * "The type that kills everyone outside of my saferoom and leaves a hell of a mess to clean up. Standard type." -- When discussing his "failsafe".
 * "I've been around for a long goddamn time. The last time I knew a bird named Nadine, I still had skin."
 * "My story? Tell you what, kid. My story's a lot like a Deathclaw's tongue. It's long, messy, and you don't want to get too personal with it. Understand?"
 * "Those mud-lovers want me dead, and they haven't extended the common fucking courtesy of telling me why." -- When discussing the Tribals.

Corpse loot

 * Dirty Pre-War Businesswear
 * Desmond's Eyeglasses
 * Sniper Rifle
 * Drum-Magazine Combat Shotgun

Appearances
appears only in the Fallout 3 add-on Point Lookout.