Jacob Forsythe

Dr. Jacob Forsythe is one of the doctors of Vault 81 in the Commonwealth

Background
Doctor Jacob Forsythe is one of the resident doctors of Vault 81. He serves as both a scientist and a physician. Working within a clinic in the vault, Jacob is responsible for the creation of medicines with his assistant Rachel, though he is judgmental of her abilities. In his role as a doctor, however, Jacob has been unaware of Holt Combes exploiting him for drugs. He expresses interest in the commonwealth, both in research and conditions other doctors operate in.

During the quest Hole in the Wall, once Austin Engill is infected with a disease Jacob will expresses concern for his condition, along with his inability to treat him. Depending on the actions of the Sole Survivor, Jacob praises or admonishes the choices made regarding Austin's condition.

Other interactions
When the Sole Survivor first talks to Dr. Forsythe, he will ask that they give a blood sample for his research due to the fact that the vault dwellers have been "genetically isolated" while living in the vault. The Sole Survivor can refuse or accept to donate, or sell blood. Giving blood is a hidden requirement to start the quest Hole in the Wall.

Appearances
Forsythe appears only in Fallout 4.