The Brain (Point Lookout)

Professor  was one of the inhabitants of Point Lookout and a member of the prestigious Calvert family before the Great War. He survived the war by preserving his brain in a jar. This has allowed him to survive for over 200 years and develop psychic powers. He communicates with the outside world as a hologram and is worshiped like a god by a local tribal cult. He uses this for his purposes, however the cult, due to their religious fervor, frequently misunderstand him leaving him very frustrated. He enlists the PC to help him kill his arch rival Desmond. He speaks in a rapid-fire voice and tends to refer to himself in the third person.

Glitches
There is a common glitch where the player will randomly be informed that The Brain is unconscious whenever they go near the boardwalk, even if he is dead, this is because the brains actual actor resides in an unopenable Pulowski Preservation Shelter hidden in the soda shop neighboring the The Homestead Motel, and is possibly falling through the map and being knocked out due to falling damage.

While near the ferris wheel, you can notice a green dot on the radar to the right of the ferris wheel, indicating a friendly NPC. This area is is reachable by use of stacked baby carraiges, or jumping from the truck on the opposite side of House of Wares to the rooftops and jumping rooftops till you get there. Upon getting on and falling through the roof, you can find this hidden occupied Pulowski Preservation Shelter with The Brain in it. However, it cannot be opened. I believe that it may be what was used to have the brain's voice talk to you in the quest "Thought Control". After blowing him up or setting him on fire with the bio-gas canisters several times, you'll get the message "The brain is unconscious." Interestingly, he glitches through the shelter while standing back up, and he has the same effect as a stealth boy, as he is transparent. But once the standing animation is complete, he goes back in the shelter.

The hidden shelter The Brain's health "The Brain is unconscious"

Invisible

Appearances
appears only in the Fallout 3 add-on Point Lookout.