Mister Sandman

Mister Sandman is a Fallout 3, Fallout: New Vegas and Fallout 4 perk.

Effects
With the Mister Sandman perk, when a character is sneaking, the option to silently kill any human or ghoul while they're sleeping is available. XP from killing the target is earned. Mister Sandman kills give a flat 50 XP per kill.

Mister Sandman is performed in sneak mode and by choosing "pickpocket" on an unfortunate sleeping victim. The game pauses and brings up a menu with the options to "murder" or "pickpocket". Choose the former to activate the perk. When used, a short murder animation follows with the character cautiously looking around and slitting the victim's throat, accompanied by a cartoony jingle.

Possession of a knife or other bladed weapon is not necessary to perform a Mister Sandman kill, even though the kill animation shows the deed performed with a combat knife.

Fallout 4

 * Damage bonus works only on weapons with silencer mod installed, making it generally useless for weapons without that option, like energy or melee weapons.
 * The bonus damage is only applied to the extra damage of a sneak attack, so with both the Sandman and Ninja perk fully levelled you get a 1 + 2.5 * 1.5 = 4.75x sneak attack multiplier.

Behind the scenes

 * The "sandman" is a folkloric character who puts sand in the eyes of little children, causing the rubbing of the eyes that is a sign of tiredness.
 * "Mister Sandman" was a song recorded by the Chordettes in the 1950s.

Bugs

 * It is still possible to perform Mr. Sandman kills on Kenny from the Point Lookout add-on and Sally from the Mothership Zeta add-on after patch 1.5.
 * It is possible that while murdering the victim, they will wake, stand up and go hostile, however, they will still die after the murdering animation is complete. It seems that when the character being killed starts attacking the murderer, no damage will actually be dealt by them.
 * In Fallout: New Vegas ordinary characters killed by this perk may fall through the floor making it difficult to loot them before they fall.
 * For unknown reasons, in some cases, the Mister Sandman animation will be replaced with with the going-to-bed animation. As soon as the player character begins to lie in the bed, the NPC will begin to get out of the bed simultaneously. Upon lying down fully, the NPC will die and the PC will immediately return to the previous crouching position.
 * The final rank of the perk seem to behave erratically on the calculation of the actual sneak attack damage multiplier on silenced weapons. A maxed Ninja perk combined with Cloak & Dagger yields the correct sneak attack modifier of 5.5x (3.5x from the first, an extra 0.7x from the latter and a rounded up 1.3x from the silenced ranged weapon bonus) while the third rank seems to lower it to 5.4x