Wild Card: Change in Management

 is a quest in Fallout: New Vegas.

Quick walkthrough
Once you discover Yes Man, he will explain Benny's plan for killing Mr. House and taking over Vegas. The player will then be able to choose to continue Benny's plans and taking on this quest. You will have to head towards the Lucky 38 penthouse, locate the chamber in which Mr. House actually resides, and choose to either disable or kill him.

Detailed walkthrough
After entering the Lucky 38 penthouse, look for a terminal on the wall near Mr. House. This terminal will allow you to unlock a hidden door leading to Mr. House's chamber. Note that, after activating the door, an alarm will sound, and the securitrons will become hostile. Behind the hidden door, there is another terminal, as well as several securitrons which will attack on sight. Activate the terminal in this room as well, to head on to the control room.

Once in the control room, there is one final terminal. Activate this terminal to release Mr. House's isolation chamber and expose him to the outside world. You can then talk to him, and decide his fate. Note that once the isolation chamber has been opened, regardless of the fate you decide for Mr. House, he will die within a year from exposure to outside contaminants.

It noteworthy that none of the terminals require science skill, allowing any level of player to simply charge through the securitrons and complete the quest.

If you decide to kill Mr. House, you will receive the note A Tragedy Has Befallen All Mankind, and the quest The House has Lost will instantly be started and failed.

The quest is complete once you either kill or disable Mr. House.