Desmond Lockheart

 is a ghoul inhabitant of Point Lookout.

A foul-mouthed ghoul who, before the Great War, used to be a British secret agent. He owns two dogs named Freki and Geri. He now lives in the Calvert Mansion, which is constantly being attacked by a tribal cult that believes the mansion is destined to burn down. Despite what may seem like a crazy religious following, they are actually being manipulated by the brain of Professor Calvert, whose only goal has been to crush Desmond for over 200 years. Part of Calvert's goal is to destroy a jamming device in Desmond's possession. This would allow Calvert to further spread his inhuman powers of mental manipulation across a wider area. The tribals attack Desmond's fortified mansion, attempting to kill him, destroy the device, and burn the mansion to the ground, but fail due to the player's interference. This beings the main story arc of Point Lookout.

Some of the dialogue from Professor Calvert hints that Desmond is British. His accent, and dialogue phrasing, seem to confirm this. It is unclear whether Desmond was based in the US when the bombs fell, or if he crossed the Atlantic after the war, as Allistair Tenpenny did.

Quotes

 * "So, my hero huh? Think you came in and rescued me right in the nick of time?" -- When you speak with him for the first time.
 * "The type that kills everyone outside of my saferoom and leaves a hell of a mess to clean up. Standard type." -- When discussing his "failsafe".
 * "I've been around for a long goddamn time. The last time I knew a bird named Nadine, I still had skin."
 * "My story? Tell you what, kid. My story's a lot like a Deathclaw's tongue. It's long, messy, and you don't want to get too personal with it. Understand?"
 * "Those mud-lovers want me dead, and they haven't extended the common fucking courtesy of telling me why." -- When discussing the Tribals.
 * "Get in here, before those cocksuckers kill you too." -- When asking you to help him fight off the Tribals.

Corpse loot

 * Dirty Pre-War Businesswear
 * Desmond's Eyeglasses
 * Sniper Rifle
 * Drum-Magazine Combat Shotgun

Appearances
appears only in the Fallout 3 add-on Point Lookout.