Syphilis

Syphilis is a sexually transmitted disease.

Background
Various characters mention the disease or make references to it, such as New Reno prostitutes, Stephen Barrett, Psycho, and James.

Appearances
Syphilis is mentioned only in Fallout 2, Fallout 3, Fallout Tactics and its demo.

Behind the scenes
The See Phyllis quest from Fallout 2 is a pun on the name of the disease.