The Overseer (Vault 101)

The Overseer is the leader of Vault 101. He is determined to keep the Vault closed. When James escapes, he thinks that the Vault 101 Dweller had something to do with it, so he sends his security after him/her. Amata seems to be his daughter and his wife is rarely spoke of except a quick sentence. He ordered the death of Jonas when the escape happened and the torture of his own daughter during the Escape. Depending on if you kill him or not Amata will react differently toward you.

If you do not kill him during your escape, he will tighten his grip on the citizens of Vault 101 which will result in a rebellion. Later in the game, If the PC travels near the Vault their Pipboy will discover the Vault 101 Emergency channel where Amata will be broadcasting a plea for help from the PC on a repeating loop, which then starts the Trouble on the Homefront quest. If you kill the Overseer when escaping from Vault 101, a new Overseer is named and you can still do the quest.

Appearances
Just like Vault 101, the Overseer appears only in Fallout 3.