Fallout 3 quests

General information
Every quest which appears in your Pip-Boy grants an achievement (on the Xbox 360 and PC) or a trophy (on the PlayStation 3) upon completion. Unmarked quests do not provide achievements/trophies.

Main quests
Main quests with names in italics can be skipped through a speech check. This is the only way to skip Galaxy News Radio (other than through unintentional glitches), though Rescue from Paradise can also be skipped through use of Child at Heart to convince MacCready to let the player into Little Lamplight. Both quests can then be completed as a side quest at any time.

All quests up to Tranquility Lane can be skipped by finding and entering Vault 112. Doing so may cause some bugs and glitches. Another way is to glitch your way into the Citadel and find the Vault Locations Computer in the A Ring. Doing so will skip you to the Picking Up The Trail quest and may cause a large number of glitches.

Unmarked quests
Aside from the major quests listed above, there are a number of minor ones that are not listed as quests in your Pip-Boy. They don't count as achievements or trophies either.

Repeatable quests
Some characters want specific items. These can be repeatedly given for xp, caps or Karma.