Nile

The Nile River is a major river that runs through Africa.

Layout
The river begins in Egypt, at the Mediterranean Sea, before flowing into Sudan. It then forks, with one branch heading into Ethiopia and the other through South Sudan and into Uganda.

Fallout 2

 * One of the criers for the Great Ananias' haunted house will refer to the mummy as the "Queen of the Nile."
 * After watching the Vault 13 surveillance tape of the death of Gruthar, the Chosen One will remark that the Enclave's blood will flow like the Nile.

Fallout 3
The river is mentioned in a bible entry on one of the terminals in the Underworld.

Far Harbor
Gilda Broscoe and Keith McKinney starred in a movie called Empire on the Nile before the war.

Appearances
The Nile River is mentioned in Fallout 2, Fallout 3, and the Fallout 4 add-on Far Harbor.