Wired Reflexes

Wired Reflexes is a Fallout 3 perk. It cannot be taken on level-up, but is available through The Replicated Man quest.

Advanced technology from the Commonwealth has increased your reaction speed, giving you a higher chance to hit in V.A.T.S. This perk increases your chance to hit by 10%. As with all perks that increase your chance to hit in V.A.T.S., this bonus is multiplicative, not additive.

Obtaining
To obtain this perk, you have to side with Dr. Zimmer in the quest The Replicated Man (betray/report A3-21). You are not required to "truly" betray A3-21, as killing Zimmer directly after receiving the perk from him will result in A3-21 being saved (and positive Karma). This path allows you to receive both quest rewards (the other being A3-21's Plasma Rifle) instead of only one reward. This path also results in no net Karma change (-200 + 200 = 0 Karma).

Correction
To obtain both rewards (wired reflexes & A3-21's Plasma Rifle) you have to warn A3-21 of Dr. Zimmer first, because if you tell Dr. Zimmer about A3-21, both Zimmer and his guard can only be rendered unconscious and all other NPCs in the room will start to attack you. However, telling A3-21 first he gives you permission to kill Zimmer, after which all you have to do is tell Zimmer about A3-21. You can still kill Zimmer, thusly saving A3-21, after informing him about the android's identity.

Bugs
As of the 1.1.035 patch, all perks that have VATS to-hit multiplier effects are broken and have no effect (similarly to Gunslinger and Commando).