Run Goodsprings Run

Run Goodsprings Run is a side quest

Detailed walkthrough

 * After witnessing the argument in the Prospector Saloon (requires finishing Back in the Saddle), find Joe Cobb leaning up against a small house at the southeastern edge of Goodsprings. He will ask the Courier to kill Ringo, a Crimson Caravan merchant who has fled to Goodsprings to escape the Powder Gangers.
 * Going too deep into dialogue with Cobb will cause the player character to fail Ghost Town Gunfight, even if they have no intention of helping the Powder Gangers.
 * Go to the Goodsprings gas station and kill Ringo, then return to Joe.
 * Joe will tell the player character to get supplies from Doc Mitchell or Chet.
 * Chet can be convinced to supply the Powder Gangers with leather armor with a successful Speech or Barter skill of 25.
 * Doc Mitchell can be lied to, then he must be convinced with a Medicine skill check of 25 to provide aid for an "injured man down by the highway."
 * If lacking in the appropriate skills, one can always buy the supplies, pickpocket the doctor, or simply kill the doctor and take the supplies.
 * Head over to Joe Cobb and give him the supplies, and help the Powder Gangers attack Goodsprings. Most non-player characters in town will become hostile, but one will receive assistance from several Powder Gangers. If not killed previously, Doc Mitchell, Easy Pete, Trudy, Sunny Smiles, and Cheyenne will gather around the Saloon and fight the Courier and the Powder Gangers.
 * Once the residents of Goodsprings are dead, one can talk to Joe and claim the reward.

Behind the scenes
Two small dialogue options were cut from the quest, pointing to an additional task Joe would have asked the player character to perform: freeing the town's bighorners.

Bugs

 * When the player character kills Ringo and informs Joe Cobb, he will ask them to get supplies from Chet and Doc Mitchell. Before getting supplies, one can kill Joe and fail the quest, but Chet and Doc Mitchell will still be locked in the 'Help the Powder Gangers' dialogue option, and one can get infinite experience, leather armor at about 50% condition, 30 9mm rounds, and Powder Ganger fame. (See Fallout: New Vegas exploits.)
 * Sometimes, the mission will not complete. Even though the Courier has killed every citizen in Goodsprings, Joe Cobb will still say that there are people to kill. When attempting to talk to Chet, he will simply say, "Can't talk now, there's a gunfight!" The mission is stuck in this limbo forever. This issue may happen because Doc Mitchell is stuck inside his house. The player character will have to go in and kill him to complete the quest.
 * Occasionally, the player character will not be able to loot Doc Mitchell's body if they kill him. Saving and reloading does not fix this bug.
 * For some reason, during the quest Run Goodsprings Run, if the player character kills Ringo and takes his deck of Caravan cards, it may freeze for a couple seconds and make the noise of scrolling down the Pip-Boy menu, then stop and the rest of his things can be taken. It does not seem to cause any problems other than freezing for a moment with the noise. Caused by each individual card being added to the player character's inventory.