Hole in the Wall

Hole in the Wall is a quest in Fallout 4.

Quick walkthrough
The Sole Survivor is tasked with getting the cure from Curie in the secret part of Vault 81. This part of the vault is dangerous, as it contains turrets and Infected mole rats. If the players character is bitten by a mole rat, the character will suffer a health penalty.

Detailed walkthrough
After talking with Erin during the Here Kitty, Kitty quest and donated blood to Dr. Forsythe, leave the vault for 24 hours or more. Austin will have been added to the vault hospital. Speaking with Dr. Penske begins Hole in the Wall. The quest may not start unless you have spoken to Dr. Penske about trying her new strain of Mutfruit.

Austin, a boy from Vault 81 was bitten by a mole rat when wandering in the secret lower level of Vault 81 and subsequently falls ill. The player character must follow Bobby De Luca to the secret entrance located in the reactor room. The player character is asked to go into that part of the vault and find a cure. During the investigation, the player character discovers the true purpose of Vault 81. The password to the locked terminal is next to the research comm terminal in the subsequent room, after this the player character finds the cure; however, there is only one dose left. The player character must decide - give it to the boy (who is in a coma now) or use it on themself, if during the quest the player character also was infected with the molerat disease.

Options

 * Give Austin the cure: If the player character gives the cure to the boy, they receive rewards including the syringer rifle and a room in Vault 81. As a side effect, the player character keeps the disease permanently (-10 max HP).
 * Use the cure on themselves: If the player character uses the Vault 81 cure on his/herself to cure the molerat disease, Austin dies and everyone in Vault 81 blames the player character.

Notable loot

 * Medicine bobblehead located on the desk in the room where Curie is located.
 * Vault 81 cure, given by Curie.
 * Mini nuke (Fallout 4) located on the eastern end of the atrium where you first encounter the brood mothers.
 * Stealth Boy (Fallout 4) in the room next to the brood mother cages.

Journal entries

 * Find the cure
 * Give cure to Dr. Forsythe
 * Watch Austin

Bugs

 * The cure can be used on both the player character and Austin if during the conversation with the doctor one can tell him to use the cure on Austin then quickly back away and use the cure on itself before it is removed from the inventory. (Got it to work on PC too. Took a few tries, but you're right, it will work, the key is moving first (with WASD) until you break the camera view, and then looking away with the mouse for the choices to disappear, and using the cure without moving (WASD). Then, still without moving, mouse back to the Dr. and it let's you choose, "You're Right" and the quest completes), (Also confirmed on Consoles - simply pan the camera away after Dr Forsythe has started moving towards Austin, and enter your Pip-Boy menu to use the cure), (It helps to first assign the Vault 81 Cure to a favorite button and then before the conversation make sure it's preselected, as soon as "Give the cure to Austin" been selected, use the cure with the assigned favorite button).
 * The Sole Survivor can become infected if the protectron that can be released is bitten, as with companions.
 * If you leave the vault before Bobby opens the secret door, he will have gone into the secret vault with the secret door still being closed, making it impossible to finish the quest. (Video evidence that verifies this statement: https://www.youtube.com/watch?v=7kd4PEp2jLY)
 * If you leave the hidden vault with the security key holotape in your inventory you will no longer be able to access the locked door to get the cure as the terminal which opens it will not register that you have the holotape anymore. Sometimes this will happen even if you do not leave the vault, and progress will become impossible without cheating.  (Toggling Clipping works well)