Wilhelm's Wharf

 is the name of a small wharf with a shack in Fallout 3. It is easily found by following the river SE from the Super Duper Mart.

Description
was a small settlement located near the Potomac river in the Washington D.C. area. The old woman Sparkle resides in the area, and acts as a local trader. Her two sons hunt for Mirelurk Meat along the river. Sparkle will mention in conversation that there were three men looking for some 'do-gooder' - a hint about the Talon Company hit squads that you will encounter throughout the game, and foreshadowing the trio of Mercs you encounter as you press on through the zone (if you choose to go here early in the game). The 'do-gooder' comment is made regardless of your actual karma.

At higher levels, the area immediately to the north of Wilhelm's Wharf features a running battle between Super Mutants and Raiders shooting at each other from opposite sides of the river. This fight usually involves 3 Raiders armed with assault rifles, and 2 Super Mutant Brutes or Super Mutant Masters armed with a minigun and a missile launcher. Both sides of combatants respawn over time. If you have Broken Steel and a high enough level, a Super Mutant Overlord spawns here.

Location
is very close to the Mirelurk nest at the Anchorage Memorial and the Tepid Sewers that Moira Brown sends you to during one of her The Wasteland Survival Guide quests. (The bridge that crosses the river has about 10+ frag mines available for collecting.)

There is a drainage culvert with a damaged grate that leads to the Hubris Comics publishing building just north of the outhouse at the north end of the wharf, near the water.

Protecting the Water Way
In Protecting the Water Way, a quest in the add-on Broken Steel, the thugs assaulting the caravans can be found here.

Notable loot
Grandma Sparkle carries an assortment of Ammunition and Aid items. The wharf has a locked refrigerator outside the shack. The key to open it on Grandma Sparkle can be pick pocketed or looted off her dead body. The fridge contains a lot of food, perfect if you're planning on visiting a Super mutant infested area in the D.C. area across the River Potomac. Bad Karma is received for killing Grandma Sparkle.

Out in the water is a sunken boat (antennae only sticking out of the water) on the end of one of the piers. On medium (PC version) setting, there are two first aid kits and two ammo boxes on the bridge, but since you are swimming in radioactive water to get to them, the value of the contents are questionable. But it is worth the 15 rads to go in there and collect drugs, stimpacks, missiles, etc.

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