A Tragedy Has Befallen All Mankind

 is a paper note obituary in Fallout: New Vegas. It is automatically given to the Courier after killing Mr. House in the Lucky 38 casino's control room during the Wild Card: Change in Management quest.

Behind the scenes
The note pays homage to Vladimir Nabokov's novel Lolita by saying "House was orphaned at an early age when his parents died in a freak accident (auto gyro, lightning)." In Lolita, the main character Humbert nonchalantly mentions the death of his mother by saying "My very photogenic mother died in a freak accident (picnic, lightning) when I was three."