Lupa's Brain

Lupa's Brain is a quest item

Gameplay
It is one of three possible replacement brains for Rex in the quest Nothin' But a Hound Dog. If it is used as a brain for Rex, he will get the Blood of the Legion perk, which increases his DT by 10.

Location
Located in The Fort during the quest Render Unto Caesar. After defeating Lupa in an arena battle, Antony will allow the Courier to take her brain. Lupa could simply be killed outside of the arena battle, but this will make the Legion hostile.

Related quests

 * Render Unto Caesar
 * Nothin' But a Hound Dog

Bugs
In the course of the quest "Nothin' But a Hound Dog", it is possible to stealthily kill Lupa and loot Lupa's brain from her corpse. If she is successfully killed without the player being noticed, Antony may not "notice" that Lupa has died and will still give you the option to fight her in the arena for her brain. If the player accepts, it is possible to obtain a second Lupa's Brain. Having 2 of the brains in your inventory will cause Dr. Henry to not recognize that you have the brain at all, making it impossible to give Rex Lupa's brain. To solve this, either revert to an earlier save, or enter in the console. Make sure that you only have one instance of Lupa's brain.