The Brain (Point Lookout)

 was one of the inhabitants of Point Lookout and a member of the prestigious Calvert family before the Great War. He survived the war by preserving his brain in a jar. This has allowed him to survive for over 200 years and develop psychic powers. He communicates with the outside world as a hologram and is worshiped like a god by a local tribal cult. He uses this for his purposes, however the cult, due to their religious fervor, frequently misunderstand him leaving him very frustrated. He enlists the PC to help him kill his arch rival Desmond. He speaks in a rapid-fire voice and tends to refer to himself in the third person. He is a nod towards the Calculator, being a brain in a machine under a vault.

Glitches
There is a common glitch where the player will randomly be informed that The Brain is unconscious whenever they go near the boardwalk, even if he is dead, this is because the brain's actual actor resides in an unopenable Pulowski Preservation Shelter hidden in the soda shop neighboring the The Homestead Motel, and is possibly falling through the map and being knocked out due to falling damage.

While near the Ferris Wheel, you can notice a green dot on the radar to the right of the ferris wheel, indicating a friendly NPC. This area is is reachable by use of stacked baby carriages, or jumping from the truck on the opposite side of House of Wares to the rooftops and jumping rooftops till you get there. Upon getting on and falling through the roof, you can find this hidden occupied Pulowski Preservation Shelter with The Brain in it. However, it cannot be opened. It is most likely here for when he talks to you during the quest Thought Control.

Trivia
The french movie "The City of Lost Children" features a professor named Krank who lives on a faraway lighthouse. He orders his minions to kidnap children, so that he can steal his dreams. His arch-nemesis is a professor named Irvin, who appears as a human brain in a bubbling water tank.

Appearances
appears only in the Fallout 3 add-on Point Lookout.