Why Can't We Be Friends?

 is a quest in Fallout: New Vegas. It is given by Philip Lem or Samuel Cooke.

Quick Walkthrough
You will need an explosives skill level of 60 to destroy the caves or 50 to destroy the caves and the vault. The explosives can be placed on the uniquely shaped green microcline rocks. The C4 will react with a nearby pocket of Potassium which will destroy the caves and the vault.

Detailed Walkthrough
The player can choose to complete one of four options. Either to kill all the fire geckos for Samuel Cooke and help his gang create bigger explosives and join with the Khans, or help Philip Lem seal access to the cave surrendering the convicts to NCR or joining with the Khans (speech 60 required), blow up the mines and vault 19 killing everyone. After talking to Lem in the Overseer's office and talking to Cooke in the other Overseer's office next door, go to the lower living quarters, there are a few mines there and geckos, so talk to your company before using the elevator to stay where they are so that they wont run into the mines because they will attack the geckos (extremely recommended in hardcore mode). From the living quarters find the common room with the pool tables and a hole in the floor. It will bring you down to the sulfur mines. On this floor are the fire geckos you have to kill to complete Cooke's quest option. Also down here is a great unique rock with green crystals in it, that you can use to blow up to seal the mines or destroy the whole place.

Cooke: Join the Khans
After you have killed all the fire geckos go back to Samuel Cooke. He then sends you to the Red Rock Canyon to meet with the the Great Khans; where you have to convince Papa Khan to join forces with the Powder Gangers in the vault. After you have convinced Papa Khan, return to Samuel Cooke to finish the quest.

Lem: Surrender to the NCR
In the caves find the green crystallized rock. Here you can choose to blow the caves up (explosives skill of 60 and 3 C4). Return to Lem and let him surrender the gang to NCR. This leaves the vault empty for personal use.

Lem: Join the Khans
In the caves find the green crystallized rock. Here you can choose to blow the caves up (explosives skill of 60 and 3 C4). Return to Lem and convince him to join the Khans (speech 60 required). He requests you act as a liaison, requiring you to visit Red Rock Canyon and talk to Papa Khan to secure their acceptance. Return to Lem once again to finish the quest.

Blow up the caves and the vault
In the caves find the green crystallized rock. Here you can choose to blow the caves up and the vault (explosives skill of 50 and 5 C4). WARNING: This will fail the quest, and you will not earn any XP. In addition, you will be transported to outside the vault, where the Quest Failed message pops up.