Randolph Safehouse

Randolph Safehouse is a quest chain in Fallout 4.

Quick walkthrough

 * 1) Pick up the dead-drop.
 * 2) Clear the indicated location of hostiles.
 * 3) Return to Desdemona for a reward.

Detailed walkthrough
Drummer Boy will approach the Sole Survivor with a mission. A safehouse believed to be long dead, Randolph Safehouse, suddenly initiates contact with Railroad HQ. Mr. Tims, the leader of said safehouse, requests help in clearing out certain locations to advance the trafficking of synth fugitives out of The Commonwealth. Desdemona thinks the sudden resurgence of Randolph is more than a bit suspicious, but gives the go-ahead on the mission and warns the Survivor to watch out for danger. This will initiate a chain of six side-missions.

Each time, the Survivor is directed to a dead-drop, a marked mailbox, which will have holotape inside. Listening to the holotape is optional, it will be Mr. Tims asking for a certain location to be cleared. Head to the location provided and kill all hostiles. This will mostly include synths, but can also include raiders, Gunners or Super mutants. After the threat is eliminated, return to Desdemona to receive a reward. Check back to Railroad HQ periodically to receive the next entry in the series.

There are 6 missions in total, the locations (at least their order) seem to be randomized, but it seems to always include University Point, and other areas frequented by synths.

After finishing the 6th mission, Desdemona will reward the Survivor with a large amount of caps, and the Institute Killer Weave, a unique mod that can be applied to any upgradable clothing item.

Bugs
If the Survivor has already cleared a location, this quest may not indicate a Quest Completion marker on the Map. If this occurs, clearing the area designated in the quest text will not advance the quest. One suggested solution is to use the following console command: If the Survivor is friendly with The Institute, synths at locations such as University Point will be friendly. The synths must be destroyed to complete the mission. This will not affect the player's standing with The Institute.